Vantage Research provides Quantitative Systems Pharmacology (QSP) Modeling and Simulation services to assist Research & Development in Pharma and LifeSciences. We work hand-in-hand with our clients to build and apply systems models to make critical decisions in various stages of the drug discovery and development lifecycle.
The pharmaceutical industry has had a declining yield of blockbuster drugs in the past few decades – a slow, expensive and failure-ridden drug development process being a significant factor. Historically, a “trial and error” approach proved successful for many decades, but in recent decades, promising breakthroughs in biomedical research have not translated to meaningful medical progress in terms of drugs delivered to the market. The industry has responded by innovating through various new technologies and approaches with the goal of precisely engineering new drugs from the ground up. QSP is one such approach.
Moving away from the traditional pharmacology’s focus on “one-gene, one-receptor, one-mechanism”, QSP adopts a systems level view, and uses mathematical models to represent physiological systems. The QSP approach combines latest biological knowledge gained from experimentation with mathematical modeling and sophisticated computational techniques – the end result is a powerful tool in the hands of R&D teams who are in the process of deciphering a drug’s mechanism of action or understanding patient-to-patient variability. This additional understanding of both the disease and drug action, is making a crucial difference to drug discovery and development.
When Vantage Research was founded in 2013, our vision was to build a center of excellence in QSP, and partner with Pharma R&D to make meaningful contributions to human health. Today, we are proudly associated with many global pharmaceutical companies and have contributed to development in areas such as diabetes, rheumatoid arthritis, hypertension, oncology, anemia and sepsis.
The QSP approach is not restricted to Pharma and LifeSciences – we also partner with the Bill and Melinda Gates Foundation to further our understanding of malnutrition in young children, and its deleterious effects on physical and cognitive development in the populations of emerging economies. This problem, when solved, will have a massive impact – from improving individual health, to accelerating GDP growth.
At Vantage Research, our mission is to apply QSP to improve human health. We welcome you to browse through our website to learn about our work.